- See 46-Down Downeast Airlines Flight 46 was a scheduled airline service in the United States from Boston's Logan International Airport to Rockland, Maine operated by Downeast Airlines. On May 30, 1979 a de Havilland Canada DHC-6 Twin Otter operating the flight crashed during a nonprecision approach to Rockland's Knox County Regional Airport.Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features.47 Meters Down: Uncaged is a 2019 survival horror film directed by Johannes Roberts and written by Roberts and Ernest Riera, and a stand alone sequel to 47 Meters Down (2017).. None of the cast from the previous film returns here. The new cast consists of Sophie Nélisse, Corinne Foxx, Brianne Tju, Sistine Stallone, Davi Santos, Khylin Rhambo, Brec Bassinger, and John Corbett.Down syndrome is a chromosomal abnormality characterized by the presence of an extra copy of genetic material on the 21st chromosome, either in whole (trisomy 21) or part (such as due to translocations).The effects of the extra copy varies greatly from individual to individual, depending on the extent of the extra copy, genetic background, environmental factors, and random chance.
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